Integration of a facile sustainable resonance Rayleigh scattering switchable-based system for feasible determination of centrophenoxine, a nootropic and antioxidant agent; application to crude materials and dosage forms.

The proposed research adheres to a certain methodology to ensure that the technique used for analyzing the centrophenoxine drug is sustainable and green. It is important to highlight that several tools that have been recently developed were utilized as potential indicators of environmental sustainability and applicability. The present research presents a novel and entirely innovative method utilizing ultrasensitive spectrofluorimetry for the detection of centrophenoxine (CPX) drug. The employed methodology in this study involved the utilization of one-step, one-pot, and direct spectrofluorimetric technique, which was found to be both efficient and environmentally sustainable in the validation and assessment of the drug. Simply, when CPX and erythrosine B reagent were combined in an acidic environment, the highly resonance Rayleigh scattering product was immediately produced. The sensitivity limits were observed to be within the range of 15-47 ng mL-1, whereas the linearity was assessed to be in the range of 50-2000 ng mL-1. The optimal settings for all modifiable parameters of the system were ascertained through an analysis of centrophenoxine-erythrosine B complexes. Moreover, the system demonstrated compliance with International Council for Harmonization (ICH) specifications without encountering any issues. The suggested process was then rated on different recent environmental safety measuring metrics to see how good it was for the environment. Fortunately, the WAC standards that combine ecological and functional elements utilizing the Green/Red/Blue (RGB 12) design also acclaimed the current analytical technique as a white one. Additionally, a new applicability evaluation tool (BAGI) was employed to estimate the practicability of the planned method in the analytical chemistry field.

Carboxymethyl Cellulose/Copper Oxide-Titanium Oxide Based Nanocatalyst Beads for the Reduction of Organic and Inorganic Pollutants.

In this work, we have developed novel beads based on carboxymethyl cellulose (CMC) encapsulated copper oxide-titanium oxide (CuO-TiO2) nanocomposite (CMC/CuO-TiO2) via Al+3 cross-linking agent. The developed CMC/CuO-TiO2 beads were applied as a promising catalyst for the catalytic reduction of organic and inorganic contaminants; nitrophenols (NP), methyl orange (MO), eosin yellow (EY) and potassium hexacyanoferrate (K3[Fe(CN)6]) in the presence of reducing agent (NaBH4). CMC/CuO-TiO2 nanocatalyst beads exhibited excellent catalytic activity in the reduction of all selected pollutants (4-NP, 2-NP, 2,6-DNP, MO, EY and K3[Fe(CN)6]). Further, the catalytic activity of beads was optimized toward 4-nitrophenol with varying its concentrations and testing different concentrations of NaBH4. Beads stability, reusability, and loss in catalytic activity were investigated using the recyclability method, in which the CMC/CuO-TiO2 nanocomposite beads were tested several times for the reduction of 4-NP. As a result, the designed CMC/CuO-TiO2 nanocomposite beads are strong, stable, and their catalytic activity has been proven.

Chitosan@Carboxymethylcellulose/CuO-Co2O3 Nanoadsorbent as a Super Catalyst for the Removal of Water Pollutants.

In this work, an efficient nanocatalyst was developed based on nanoadsorbent beads. Herein, carboxymethyl cellulose-copper oxide-cobalt oxide nanocomposite beads (CMC/CuO-Co2O3) crosslinked by using AlCl3 were successfully prepared. The beads were then coated with chitosan (Cs), Cs@CMC/CuO-Co2O3. The prepared beads, CMC/CuO-Co2O3 and Cs@CMC/CuO-Co2O3, were utilized as adsorbents for heavy metal ions (Ni, Fe, Ag and Zn). By using CMC/CuO-Co2O3 and Cs@CMC/CuO-Co2O3, the distribution coefficients (Kd) for Ni, Fe, Ag and Zn were (41.166 and 6173.6 mLg-1), (136.3 and 1500 mLg-1), (20,739.1 and 1941.1 mLg-1) and (86.9 and 2333.3 mLg-1), respectively. Thus, Ni was highly adsorbed by Cs@CMC/CuO-Co2O3 beads. The metal ion adsorbed on the beads were converted into nanoparticles by treating with reducing agent (NaBH4) and named Ni/Cs@CMC/CuO-Co2O3. Further, the prepared nanoparticles-decorated beads (Ni/Cs@CMC/CuO-Co2O3) were utilized as nanocatalysts for the reduction of organic and inorganic pollutants (4-nitophenol, MO, EY dyes and potassium ferricyanide K3[Fe(CN)6]) in the presence of NaBH4. Among all catalysts, Ni/Cs@CMC/CuO-Co2O3 had the highest catalytic activity toward MO, EY and K3[Fe(CN)6], removing up to 98% in 2.0 min, 90 % in 6.0 min and 91% in 6.0 min, respectively. The reduction rate constants of MO, EY, 4-NP and K3[Fe(CN)6] were 1.06 × 10-1, 4.58 × 10-3, 4.26 × 10-3 and 5.1 × 10-3 s-1, respectively. Additionally, the catalytic activity of the Ni/Cs@CMC/CuO-Co2O3 beads was effectively optimized. The stability and recyclability of the beads were tested up to five times for the catalytic reduction of MO, EY and K3[Fe(CN)6]. It was confirmed that the designed nanocomposite beads are ecofriendly and efficient with high strength and stability as catalysts for the reduction of organic and inorganic pollutants.

Metal nanoparticles supported chitosan coated carboxymethyl cellulose beads as a catalyst for the selective removal of 4-nitrophenol.

In the area of water pollution treatment, the coupling of biopolymers with metal/metal nanoparticles is getting a lot of interest these days. Herein, carboxymethyl cellulose (CMC) beads and chitosan (Cs) coated CMC beads were employed as a support for copper nanoparticles, (Cu/CMC) and (Cu/Cs@CMC), respectively. Following that, a reducing agent (NaBH4) was used to convert Cu/CMC and Cu/Cs@CMC beads to zero valent. The developed beads were employed for catalytic reductions of nitrophenol, dyes, and potassium hexacyanoferrate (III) in their mixed solution with NaBH4. Cu/Cs@CMC beads were more efficient compared to Cu/CMC beads toward selected pollutants. The reduction rate constants of 4-NP, MO, EY and K3[Fe(CN)6] by utilizing Cu/Cs@CMC were 3.8 × 10-1, 4.0 × 10-1, 1.4 × 10-1 and 4.48 × 10-1 min-1, respectively. Further, the catalytic activity of the Cu/Cs@CMC beads were optimized using 4-NP as a model compound for this study. Cu/Cs@CMC beads were able to use up to three cycles compared to Cu/CMC beads without losing catalytic activity in the reduction of 4-NP, according to the recyclability and reusability study of both beads. The chitosan coating beads Cu/Cs@CMC was simply prepared and have good catalytic activity, recyclable, and more efficient than Cu/CMC beads due to their high strength and stability.

Super adsorption performance of carboxymethyl cellulose/copper oxide-nickel oxide nanocomposite toward the removal of organic and inorganic pollutants.

A novel nanocomposite bead based on polymeric matrix of carboxymethyl cellulose and copper oxide-nickel oxide nanoparticles was synthesized, characterized, and applied for adsorptive removal of inorganic and organic contaminants at trace level of part per million (mgL-1) from aqueous sample. Carboxymethyl cellulose/copper oxide-nickel oxide (CMC/CuO-NiO) adsorbent beads were selective toward the removal of Pb(II) among other metal ions. The removal percentage of Pb(II) was more than 99% with 3 mgL-1. The waste beads after Pb (II) adsorption (Pb@CMC/CuO-NiO) and CMC/CuO-NiO nanocomposite beads were employed as adsorbents for removing of various dyes. It was found that Pb@CMC/CuO-NiO can be reused as adsorbent for the removal of Congo Red (CR), while CMC/CuO-NiO nanocomposite beads were more selective for removal of Eosin Yellow (EY) from aqueous media. The adsorption of CR and EY was optimized, and the removal percentages were 93% and 96.4%, respectively. The influence of different parameters was studied on the uptake capacity of Pb(II), CR, and EY, and lastly, the CMC/CuO-NiO beads exhibited responsive performance in relation to pH and other parameters. Thus, the prepared CMC/CuO-NiO beads were found to be a smart material which is effective and played super adsorption performance in the removal of Pb(II), CR, and EY from aqueous solution. These features make CMC/CuO-NiO beads suitable for numerous scientific and industrial applications and may be used as an alternative to high-cost commercial adsorbents.

Carboxymethyl cellulose nanocomposite beads as super-efficient catalyst for the reduction of organic and inorganic pollutants.

Carboxymethyl cellulose/copper oxide-nickel oxide (CMC/CuO-NiO) nanocomposite beads were prepared by facile, simple and environmentally friendly method. Initially, CuO-NiO was prepared and applied for the catalytic reduction of 4-nitrophenol (4-NP). The results showed that CuO-NiO demonstrate high catalytic activity toward the reduction of 4-NP to 4-aminophenol (4-AP) with a rate constant of 2.97 × 10-2 s-1. Further, CuO-NiO were well-dispersed in the polymeric matrix of carboxymethyl cellulose to prepare CMC/CuO-NiO beads. CMC/CuO-NiO nanocomposite beads were also applied to catalyze the reduction of potassium ferrocyanide (K3Fe (CN)6), 4-NP, Congo red (CR) and Eosin yellow (EY) in the presence of sodium borohydride. Experimental data indicated that CMC/CuO-NiO nanocomposite has higher catalytic activity and high rate constant compared to CuO-NiO. The rate constant found to be 6.88 × 10-2, 6.27 × 10-2, 1.89 × 10-2 and 2.43 × 10-2 for K3Fe(CN)6, 4-NP, CR and EY, respectively, using 5 mg CMC/CuO-NiO beads. FE-SEM, EDX, FTER, XRD and XPS were used to characterize the nanocomposites. CMC/CuO-NiO beads catalytically reduced up to 95-99% of K3Fe(CN)6, 4-NP, CR and EY within 40, 60, 120 and 120 s. CMC/CuO-NiO beads were found more selective for the reduction of 4-NP. The catalytic reduction performance of CMC/CuO-NiO beads was optimized by studying the influence of different parameters on the catalytic reduction of 4-NP. Hence, the effective and super catalytic performance toward the reduction of different organic and inorganic pollutants makes CMC/CuO-NiO beads a smart material and suitable for numerous scientific and industrial applications and may be used as an alternative to high-cost commercial catalysts.

ICE Concentration Linked with Extractive Stirrer (ICECLES).

Trace and ultra-trace analysis can be difficult to achieve, especially for polar, more volatile, and/or thermally unstable analytes. A novel technique, coined ICE Concentration Linked with Extractive Stirrer (ICECLES), may help address this problem. The implementation of ICECLES described here combines stir bar sorptive extraction (SBSE) with freeze concentration (FC), where an aqueous solution is frozen during SBSE in order to concentrate analytes into a polydimethylsiloxane (PDMS) coated stir bar. Five test probe molecules with a range of log Kows (2-butanol, benzyl alcohol, benzaldehyde, dimethyl trisulfide and bromobenzene) were prepared from aqueous solutions using ICECLES. Thermal desorption gas-chromatography mass-spectrometry was then used to quantify these analytes. Parameters affecting the performance of ICECLES (e.g., freeze rate) were evaluated, with extraction at lower speeds resulting in higher extraction efficiencies, whereas the freeze rate and initial analyte concentration only had a minor effect. ICECLES produced much higher extraction efficiencies than SBSE alone, with signal enhancements of up to 474× SBSE. ICECLES also provided excellent reproducibility and lower LODs than SBSE for all compounds tested. ICECLES performed well when used to analyze multiple triazine pesticides and breakdown products in environmental surface waters. Overall, the ICECLES technique was excellent at preparing aqueous samples for trace analysis and shows promise as a novel analytical sample preparation technology.

Determination of dimethyl trisulfide in rabbit blood using stir bar sorptive extraction gas chromatography-mass spectrometry.

Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current Food and Drug Administration approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations concerning large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate (a relatively nontoxic cyanide metabolite), is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS from any matrix is not currently available, one will be vital for the approval of DMTS as a therapeutic agent against cyanide poisoning. Hence, a stir bar sorptive extraction (SBSE) gas chromatography - mass spectrometry (GC-MS) method was developed and validated for the analysis of DMTS from rabbit whole blood. Following acid denaturation of blood, DMTS was extracted into a polydimethylsiloxane-coated stir bar. The DMTS was then thermally desorbed from the stir bar and analyzed by GC-MS. The limit of detection of DMTS using this method was 0.06µM with dynamic range from 0.5-100µM. For quality control standards, the precision, as measured by percent relative standard deviation, was below 10%, and the accuracy was within 15% of the nominal concentration. The method described here will allow further investigations of DMTS as a promising antidote for cyanide poisoning.